Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin

The current standard of care for moderate to severe ischemic stroke is thrombolytic therapy with tissue plasminogen activator (tPA). Treatment with tPA can significantly improve neurologic outcomes; however, thrombolytic therapy is associated with an increased risk of intracerebral hemorrhage (ICH)....

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Detalles Bibliográficos
Autores principales: Goncalves, Andreia, Su, Enming J., Muthusamy, Arivalagan, Zeitelhofer, Manuel, Torrente, Daniel, Nilsson, Ingrid, Protzmann, Jil, Fredriksson, Linda, Eriksson, Ulf, Antonetti, David A., Lawrence, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335502/
https://www.ncbi.nlm.nih.gov/pubmed/35576527
http://dx.doi.org/10.1182/blood.2021014958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335502/
https://www.ncbi.nlm.nih.gov/pubmed/35576527
http://dx.doi.org/10.1182/blood.2021014958

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