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Site-Specific Protein Labeling and Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase

[Image: see text] Asparaginyl endopeptidases (AEPs) have recently been widely utilized for peptide and protein modification. Labeling is however restricted to protein termini, severely limiting flexibility and scope in creating diverse conjugates as needed for therapeutic and diagnostic applications...

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Detalles Bibliográficos
Autores principales: Fottner, Maximilian, Heimgärtner, Johannes, Gantz, Maximilian, Mühlhofer, Rahel, Nast-Kolb, Timon, Lang, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335880/
https://www.ncbi.nlm.nih.gov/pubmed/35850488
http://dx.doi.org/10.1021/jacs.2c02191