Heterologous saRNA Prime, DNA Dual-Antigen Boost SARS-CoV-2 Vaccination Elicits Robust Cellular Immunogenicity and Cross-Variant Neutralizing Antibodies

We assessed if immune responses are enhanced in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines: a next-generation human adenovirus serotype 5 (hAd5)-vectored dual-antigen spike (S) and nucleocapsid (N) vaccine (AdS+N) and a self-amplifying and -adjuvant...

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Detalles Bibliográficos
Autores principales: Rice, Adrian, Verma, Mohit, Voigt, Emily, Battisti, Peter, Beaver, Sam, Reed, Sierra, Dinkins, Kyle, Mody, Shivani, Zakin, Lise, Tanaka, Shiho, Morimoto, Brett, Olson, C. Anders, Gabitzsch, Elizabeth, Safrit, Jeffrey T., Spilman, Patricia, Casper, Corey, Soon-Shiong, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335885/
https://www.ncbi.nlm.nih.gov/pubmed/35911728
http://dx.doi.org/10.3389/fimmu.2022.910136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335885/
https://www.ncbi.nlm.nih.gov/pubmed/35911728
http://dx.doi.org/10.3389/fimmu.2022.910136

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