Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism

[Image: see text] The fungal metabolite collybolide has attracted attention as a non-nitrogenous, potent, and biased agonist of the kappa-opioid receptor (KOR). Here, we report a 10-step asymmetric synthesis of this complex sesquiterpene that enables facile access to either enantiomer. The synthesis...

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Detalles Bibliográficos
Autores principales: Shevick, Sophia L., Freeman, Stephan M., Tong, Guanghu, Russo, Robin J., Bohn, Laura M., Shenvi, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335922/
https://www.ncbi.nlm.nih.gov/pubmed/35912357
http://dx.doi.org/10.1021/acscentsci.2c00442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335922/
https://www.ncbi.nlm.nih.gov/pubmed/35912357
http://dx.doi.org/10.1021/acscentsci.2c00442

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