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Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin–p53 interaction

BACKGROUND: Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to muscle weakness in the elderly, to alter the development and function of the skeletal muscles. Stress-induced premature senescence (SIPS), a state of cel...

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Detalles Bibliográficos
Autores principales: Xiang, Yaoxian, You, Zongqi, Huang, Xinying, Dai, Junxi, Zhang, Junpeng, Nie, Shuqi, Xu, Lei, Jiang, Junjian, Xu, Jianguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335985/
https://www.ncbi.nlm.nih.gov/pubmed/35906707
http://dx.doi.org/10.1186/s13395-022-00302-y