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Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia

BACKGROUND: SPG11-linked hereditary spastic paraplegia is characterized by multisystem neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive spasticity and weakness. Severe cognitive symptoms are present in the majority of SPG11 patients, but a systematic and mul...

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Detalles Bibliográficos
Autores principales: Utz, Kathrin S., Kohl, Zacharias, Marterstock, Dominique Cornelius, Doerfler, Arnd, Winkler, Jürgen, Schmidt, Manuel, Regensburger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336101/
https://www.ncbi.nlm.nih.gov/pubmed/35906604
http://dx.doi.org/10.1186/s13023-022-02451-1