Repositioning of Lansoprazole as a Protective Agent Against Cisplatin-Induced Ototoxicity

Cisplatin (CDDP) is a well-known chemotherapeutic drug approved for various cancers. However, CDDP accumulates in the inner ear cochlea via organic cation transporter 2 (OCT2) and causes ototoxicity, which is a major clinical limitation. Since lansoprazole (LPZ), a proton pump inhibitor, is known to...

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Detalles Bibliográficos
Autores principales: Wakai, Eri, Ikemura, Kenji, Mizuno, Toshiro, Takeuchi, Kazuhiko, Tamaru, Satoshi, Okuda, Masahiro, Nishimura, Yuhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336179/
https://www.ncbi.nlm.nih.gov/pubmed/35910376
http://dx.doi.org/10.3389/fphar.2022.896760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336179/
https://www.ncbi.nlm.nih.gov/pubmed/35910376
http://dx.doi.org/10.3389/fphar.2022.896760

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