Cargando…

Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease

Demyelination is a common pathological feature of a large number of neurodegenerative diseases including multiple sclerosis and Huntington's disease (HD). Laquinimod (LAQ) has been found to have therapeutic effects on multiple sclerosis and HD. However, the mechanism underlying LAQ's thera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Peng, Liu, Qiong, Pan, Yongcheng, Yang, Weili, Yang, Su, Wei, Wenjie, Chen, Xingxing, Hong, Yan, Bai, Dazhang, Li, Xiao‐Jiang, Li, Shihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336218/ https://www.ncbi.nlm.nih.gov/pubmed/32270922 http://dx.doi.org/10.15252/embr.201949783

Ejemplares similares

Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2
por: Koltes, James E, et al.
Publicado: (2015)

Myelination, Dysmyelination, and Demyelination
por: Jean Harry, G., et al.
Publicado: (1998)

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response
por: Chen, Xingxing, et al.
Publicado: (2020)

Variable skeletal phenotypes associated with biallelic variants in PRKG2
por: Pagnamenta, Alistair T, et al.
Publicado: (2022)

Upregulation of cGMP‐dependent Protein Kinase (PRKG1) in the Development of Adolescent Idiopathic Scoliosis
por: Hou, Cang‐long, et al.
Publicado: (2020)

Prkg2 regulates alveolar type 2-mediated re-alveolarization
por: Zhang, Mo, et al.
Publicado: (2022)

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO
por: de la Fuente-Alonso, Andrea, et al.
Publicado: (2021)

PRKG2 Splice Site Variant in Dogo Argentino Dogs with Disproportionate Dwarfism
por: Rudd Garces, Gabriela, et al.
Publicado: (2021)

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
por: Weil, Marie-Theres, et al.
Publicado: (2016)

Dock3 protects myelin in the cuprizone model for demyelination
por: Namekata, K, et al.
Publicado: (2014)

Effects of CNS Demyelination and Myelin Recovery on Urinary Physiology
por: Ramasamy, Ramalakshmi, et al.
Publicado: (2020)

Polymorphism detection of PRKG2 gene and its association with the number of thoracolumbar vertebrae and carcass traits in Dezhou donkey
por: Wang, Tianqi, et al.
Publicado: (2023)

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis
por: Cunha, Maria Inês, et al.
Publicado: (2020)

Sphingomyelin as a myelin biomarker in CSF of acquired demyelinating neuropathies
por: Capodivento, Giovanna, et al.
Publicado: (2017)

Study of myelin structure changes during the nerve fibers demyelination
por: Rodionova, Natalia N., et al.
Publicado: (2017)

Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination
por: Tea, Fiona, et al.
Publicado: (2019)

Myelin replacement triggered by single-cell demyelination in mouse cortex
por: Snaidero, Nicolas, et al.
Publicado: (2020)

Myelin Protection by Ursolic Acid in Cuprizone-Induced Demyelination in Mice
por: Honarvar, Fatemeh, et al.
Publicado: (2019)

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model
por: Jiang, Wenxiao, et al.
Publicado: (2015)

Therapeutic intervention in relapsing autoimmune demyelinating disease through induction of myelin-specific regulatory CD8 T cell responses
por: Brate, Ashley A., et al.
Publicado: (2019)

A post-GWAS confirming effects of PRKG1 gene on milk fatty acids in a Chinese Holstein dairy population
por: Shi, Lijun, et al.
Publicado: (2019)

Brain region dependent molecular signatures and myelin repair following chronic demyelination
por: Samtani, Grace, et al.
Publicado: (2023)

Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
por: Zhang, Min, et al.
Publicado: (2019)

cGMP-Prkg1 signaling PDE5 inhibition shelter cochlear hair cells and hearing function
por: Knipper, Marlies, et al.
Publicado: (2013)

Exome sequencing reveals a de novo PRKG1 mutation in a sporadic patient with aortic dissection
por: Zhang, Wenwen, et al.
Publicado: (2018)

Downexpression of miR-200c-3p Contributes to Achalasia Disease by Targeting the PRKG1 Gene
por: Micale, Lucia, et al.
Publicado: (2022)

Myelin morphology and axon pathology in demyelination during experimental autoimmune encephalomyelitis
por: Bando, Yoshio
Publicado: (2015)

Myelin Oligodendrocyte Glycoprotein: Deciphering a Target in Inflammatory Demyelinating Diseases
por: Peschl, Patrick, et al.
Publicado: (2017)

Insights into White Matter Defect in Huntington’s Disease
por: Sun, Yize, et al.
Publicado: (2022)

Neuroinflammation in Huntington’s disease: From animal models to clinical therapeutics
por: Jia, Qingqing, et al.
Publicado: (2022)

Multiple pathways contribute to the pathogenesis of Huntington disease
por: Li, Shihua, et al.
Publicado: (2006)

Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease
por: Rosas, H.D., et al.
Publicado: (2018)

Glial Growth Factor/Neuregulin Inhibits Schwann Cell Myelination and Induces Demyelination
por: Zanazzi, George, et al.
Publicado: (2001)

Intractable Hiccup in Demyelinating Disease with Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody
por: Akaishi, Tetsuya, et al.
Publicado: (2016)

EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination
por: Rutkowska, Aleksandra, et al.
Publicado: (2017)

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
por: Chami, Marwan, et al.
Publicado: (2017)

Increased levels of myelin basic protein transcripts gene in virus-induced demyelination
por: Kristensson, K., et al.
Publicado: (1986)

Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult
por: Ziaei, Amin, et al.
Publicado: (2022)

Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models
por: Miller, John A., et al.
Publicado: (2022)

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease
por: Schäffner, Erik, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7ceqqk5k1fkcv83m44p8nh1vrb