Junctional instability in neuroepithelium and network hyperexcitability in a focal cortical dysplasia human model

Focal cortical dysplasia is a highly epileptogenic cortical malformation with few treatment options. Here, we generated human cortical organoids from patients with focal cortical dysplasia type II. Using this human model, we mimicked some focal cortical dysplasia hallmarks, such as impaired cell pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Avansini, Simoni H, Puppo, Francesca, Adams, Jason W, Vieira, Andre S, Coan, Ana C, Rogerio, Fabio, Torres, Fabio R, Araújo, Patricia A O R, Martin, Mariana, Montenegro, Maria A, Yasuda, Clarissa L, Tedeschi, Helder, Ghizoni, Enrico, França, Andréa F E C, Alvim, Marina K M, Athié, Maria C, Rocha, Cristiane S, Almeida, Vanessa S, Dias, Elayne V, Delay, Lauriane, Molina, Elsa, Yaksh, Tony L, Cendes, Fernando, Lopes Cendes, Iscia, Muotri, Alysson R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336577/
https://www.ncbi.nlm.nih.gov/pubmed/34957478
http://dx.doi.org/10.1093/brain/awab479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9336577/
https://www.ncbi.nlm.nih.gov/pubmed/34957478
http://dx.doi.org/10.1093/brain/awab479

Ejemplares similares