Targeting strategies in the treatment of fumarate hydratase deficient renal cell carcinoma

Fumarate hydratase (FH) - deficient renal cell carcinoma (FHdRCC) is a rare aggressive subtype of RCC caused by a germline or sporadic loss-of-function mutation in the FH gene. Here, we summarize how FH deficiency results in the accumulation of fumarate, which in turn leads to activation of hypoxia-...

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Detalles Bibliográficos
Autores principales: Lindner, Andrea Katharina, Tulchiner, Gennadi, Seeber, Andreas, Siska, Peter J., Thurnher, Martin, Pichler, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337267/
https://www.ncbi.nlm.nih.gov/pubmed/35912170
http://dx.doi.org/10.3389/fonc.2022.906014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337267/
https://www.ncbi.nlm.nih.gov/pubmed/35912170
http://dx.doi.org/10.3389/fonc.2022.906014

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