Cargando…

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells

As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research. Indeed, MRGPRX2 is believed to be a major component of pseudo-allergic reactions to drugs and of neuropeptide-elicited MC a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhao, Li, Zhuoran, Bal, Gürkan, Franke, Kristin, Zuberbier, Torsten, Babina, Magda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Allergy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337275/ https://www.ncbi.nlm.nih.gov/pubmed/35910860 http://dx.doi.org/10.3389/falgy.2022.930233

Ejemplares similares

MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G(αi), G(αq), Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
por: Wang, Zhao, et al.
Publicado: (2022)

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK
por: Babina, Magda, et al.
Publicado: (2021)

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming
por: Wang, Zhao, et al.
Publicado: (2019)

CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells
por: Franke, Kristin, et al.
Publicado: (2023)

Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells
por: Franke, Kristin, et al.
Publicado: (2023)

Phosphorylation of β-arrestin2 at Thr(383) by MEK underlies β-arrestin-dependent activation of Erk1/2 by GPCRs
por: Cassier, Elisabeth, et al.
Publicado: (2017)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Cytokines Stimulated by IL-33 in Human Skin Mast Cells: Involvement of NF-κB and p38 at Distinct Levels and Potent Co-Operation with FcεRI and MRGPRX2
por: Franke, Kristin, et al.
Publicado: (2021)

Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells
por: Vibhuti, Arpana, et al.
Publicado: (2011)

Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2
por: Yao, Ciyu, et al.
Publicado: (2023)

β-Arrestin1 and β-Arrestin2 Are Required to Support the Activity of the CXCL12/HMGB1 Heterocomplex on CXCR4
por: D’Agostino, Gianluca, et al.
Publicado: (2020)

Authentic and Ectopically Expressed MRGPRX2 Elicit Similar Mechanisms to Stimulate Degranulation of Mast Cells
por: Lazki-Hagenbach, Pia, et al.
Publicado: (2021)

Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization
por: Chompunud Na Ayudhya, Chalatip, et al.
Publicado: (2021)

How “Neuronal” Are Human Skin Mast Cells?
por: Babina, Magda, et al.
Publicado: (2022)

The single nucleotide β -arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
por: ŞENSOY, Özge
Publicado: (2020)

β-Arrestin2 arrests the clearance of tau in FTLD
por: Thathiah, Amantha
Publicado: (2020)

Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin
por: Kahsai, Alem W., et al.
Publicado: (2023)

Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart
por: Lymperopoulos, Anastasios, et al.
Publicado: (2019)

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
por: DeFea, K.A., et al.
Publicado: (2000)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

β-Arrestin2 is increased in liver fibrosis in humans and rodents
por: Schierwagen, Robert, et al.
Publicado: (2020)

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation
por: Coutinho, Agnes E., et al.
Publicado: (2013)

Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants
por: Wu, Yuxin, et al.
Publicado: (2022)

CXCR7: a β-arrestin-biased receptor that potentiates cell migration and recruits β-arrestin2 exclusively through Gβγ subunits and GRK2
por: Nguyen, Huong Thi, et al.
Publicado: (2020)

SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell degranulation, in an in vitro model for non-IgE-mediated hypersensitivity
por: Quan, Paola Leonor, et al.
Publicado: (2022)

SUN-479 Role of β-arrestin2 in ERK 1/2 Activation Mediated by Corticotropin-Releasing Factor Receptor Type 1
por: Parra Mercado, Gabriela, et al.
Publicado: (2019)

Roles of Dopamine D(2) Receptor Subregions in Interactions with β-Arrestin2
por: Zhang, Xiaohan, et al.
Publicado: (2016)

Multifaceted role of β-arrestins in inflammation and disease
por: Sharma, Deepika, et al.
Publicado: (2015)

β-Arrestin-Dependent Deactivation of Mouse Melanopsin
por: Cameron, Evan G., et al.
Publicado: (2014)

βArrestin2 Mediates Renal Cell Carcinoma Tumor Growth
por: Masannat, Jude, et al.
Publicado: (2018)

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling
por: Kliewer, Andrea, et al.
Publicado: (2020)

β-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis
por: Fu, Dong, et al.
Publicado: (2019)

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension
por: Willets, Jonathon M., et al.
Publicado: (2015)

The Role of β-Arrestins in Regulating Stem Cell Phenotypes in Normal and Tumorigenic Cells
por: Kallifatidis, Georgios, et al.
Publicado: (2020)

Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1
por: Huang, Weijiao, et al.
Publicado: (2020)

β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
por: Liu, Yang, et al.
Publicado: (2022)

Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases
por: Liu, Haiping, et al.
Publicado: (2023)

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility
por: Kim, Jihee, et al.
Publicado: (2018)

Lipids and Phosphorylation Conjointly Modulate Complex Formation of β(2)-Adrenergic Receptor and β-arrestin2
por: Pluhackova, Kristyna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_elmlttbesfh1qu84cgeh7rmn4p