Cargando…
Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice
Myrciaria cauliflora is a functional food rich in anthocyanins, possessing antioxidative and anti-inflammatory properties. Our previous results demonstrated M. cauliflora extract (MCE) had beneficial effects in diabetic nephropathy (DN) and via the inhibition of Ras/PI3K/Akt and kidney fibrosis-rela...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taiwan Food and Drug Administration
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337277/ https://www.ncbi.nlm.nih.gov/pubmed/28911610 http://dx.doi.org/10.1016/j.jfda.2016.03.009 |
_version_ | 1784759716438605824 |
---|---|
author | Hsu, Jeng-Dong Wu, Chia-Chun Hung, Chi-Nan Wang, Chau-Jong Huang, Hui-Pei |
author_facet | Hsu, Jeng-Dong Wu, Chia-Chun Hung, Chi-Nan Wang, Chau-Jong Huang, Hui-Pei |
author_sort | Hsu, Jeng-Dong |
collection | PubMed |
description | Myrciaria cauliflora is a functional food rich in anthocyanins, possessing antioxidative and anti-inflammatory properties. Our previous results demonstrated M. cauliflora extract (MCE) had beneficial effects in diabetic nephropathy (DN) and via the inhibition of Ras/PI3K/Akt and kidney fibrosis-related proteins. The purpose of this study was to assess the benefit of MCE in diabetes associated with kidney inflammation and glycemic regulation in streptozotocin–nicotinamide (STZ/NA)-induced diabetic mice. Compared with the untreated diabetic group, MCE significantly improved blood glucose and serum biochemical characteristic levels. Exposure to MCE increased antioxidative enzyme activity and diminished reactive oxygen synthesis. Mice receiving MCE supplementation had reduced intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), colony stimulating factor 1 (CSF-1), interleukin-1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α) levels compared to the untreated diabetic mice. Inflammatory and fibrotic related proteins such as collagen IV, fibronectin, Janus kinase (JAK), phosphorylated signal transducer and activator of transcription 3 (STAT3), protein kinase C beta (PKC-β), and nuclear factor kappa B (NF-κB) were also inhibited by MCE treatment in STZ/NA mice. These results suggest that MCE may be used as a hypoglycemic agent and antioxidant in Type 2 diabetic mice. |
format | Online Article Text |
id | pubmed-9337277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taiwan Food and Drug Administration |
record_format | MEDLINE/PubMed |
spelling | pubmed-93372772022-08-09 Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice Hsu, Jeng-Dong Wu, Chia-Chun Hung, Chi-Nan Wang, Chau-Jong Huang, Hui-Pei J Food Drug Anal Original Article Myrciaria cauliflora is a functional food rich in anthocyanins, possessing antioxidative and anti-inflammatory properties. Our previous results demonstrated M. cauliflora extract (MCE) had beneficial effects in diabetic nephropathy (DN) and via the inhibition of Ras/PI3K/Akt and kidney fibrosis-related proteins. The purpose of this study was to assess the benefit of MCE in diabetes associated with kidney inflammation and glycemic regulation in streptozotocin–nicotinamide (STZ/NA)-induced diabetic mice. Compared with the untreated diabetic group, MCE significantly improved blood glucose and serum biochemical characteristic levels. Exposure to MCE increased antioxidative enzyme activity and diminished reactive oxygen synthesis. Mice receiving MCE supplementation had reduced intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1), colony stimulating factor 1 (CSF-1), interleukin-1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α) levels compared to the untreated diabetic mice. Inflammatory and fibrotic related proteins such as collagen IV, fibronectin, Janus kinase (JAK), phosphorylated signal transducer and activator of transcription 3 (STAT3), protein kinase C beta (PKC-β), and nuclear factor kappa B (NF-κB) were also inhibited by MCE treatment in STZ/NA mice. These results suggest that MCE may be used as a hypoglycemic agent and antioxidant in Type 2 diabetic mice. Taiwan Food and Drug Administration 2016-06-06 /pmc/articles/PMC9337277/ /pubmed/28911610 http://dx.doi.org/10.1016/j.jfda.2016.03.009 Text en © 2016 Taiwan Food and Drug Administration https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Original Article Hsu, Jeng-Dong Wu, Chia-Chun Hung, Chi-Nan Wang, Chau-Jong Huang, Hui-Pei Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title | Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title_full | Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title_fullStr | Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title_full_unstemmed | Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title_short | Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
title_sort | myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337277/ https://www.ncbi.nlm.nih.gov/pubmed/28911610 http://dx.doi.org/10.1016/j.jfda.2016.03.009 |
work_keys_str_mv | AT hsujengdong myrciariacaulifloraextractimprovesdiabeticnephropathyviasuppressionofoxidativestressandinflammationinstreptozotocinnicotinamidemice AT wuchiachun myrciariacaulifloraextractimprovesdiabeticnephropathyviasuppressionofoxidativestressandinflammationinstreptozotocinnicotinamidemice AT hungchinan myrciariacaulifloraextractimprovesdiabeticnephropathyviasuppressionofoxidativestressandinflammationinstreptozotocinnicotinamidemice AT wangchaujong myrciariacaulifloraextractimprovesdiabeticnephropathyviasuppressionofoxidativestressandinflammationinstreptozotocinnicotinamidemice AT huanghuipei myrciariacaulifloraextractimprovesdiabeticnephropathyviasuppressionofoxidativestressandinflammationinstreptozotocinnicotinamidemice |