The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response

Interindividual variation is important in the response to metformin as the first-line therapy for type-2 diabetes mellitus (T2DM). Considering that OCT1 and MATE1 transporters determine the metformin pharmacokinetics, this study aimed to investigate the influence of SLC22A1 and SLC47A1 variants on t...

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Detalles Bibliográficos
Autores principales: Ningrum, Vitarani Dwi Ananda, Sadewa, Ahmad Hamim, Ikawati, Zullies, Yuliwulandari, Rika, Ikhsan, M. Robikhul, Fajriyah, Rohmatul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337647/
https://www.ncbi.nlm.nih.gov/pubmed/35905099
http://dx.doi.org/10.1371/journal.pone.0271410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337647/
https://www.ncbi.nlm.nih.gov/pubmed/35905099
http://dx.doi.org/10.1371/journal.pone.0271410

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