Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases

Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of a phosphonyl diazo reage...

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Detalles Bibliográficos
Autores principales: Ren, Xinkun, Chandgude, Ajay L., Carminati, Daniela M., Shen, Zhuofan, Khare, Sagar D., Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337741/
https://www.ncbi.nlm.nih.gov/pubmed/35974764
http://dx.doi.org/10.1039/d2sc01965e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337741/
https://www.ncbi.nlm.nih.gov/pubmed/35974764
http://dx.doi.org/10.1039/d2sc01965e

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