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Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases
Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of a phosphonyl diazo reage...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337741/ https://www.ncbi.nlm.nih.gov/pubmed/35974764 http://dx.doi.org/10.1039/d2sc01965e |