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Site specific NMR characterization of abeta-40 oligomers cross seeded by abeta-42 oligomers

Extracellular accumulation of β amyloid peptides of 40 (Aβ(40)) and 42 residues (Aβ(42)) has been considered as one of the hallmarks in the pathology of Alzheimer's disease. In this work, we are able to prepare oligomeric aggregates of Aβ with uniform size and monomorphic structure. Our experim...

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Detalles Bibliográficos
Autores principales: Chang, Han-Wen, Ma, Ho-I., Wu, Yi-Shan, Lee, Ming-Che, Chung-Yueh Yuan, Eric, Huang, Shing-Jong, Cheng, Yu-Sheng, Wu, Meng-Hsin, Tu, Ling-Hsien, Chan, Jerry Chun Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337746/
https://www.ncbi.nlm.nih.gov/pubmed/35974768
http://dx.doi.org/10.1039/d2sc01555b