DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies

Antibody-Drug Conjugates (ADCs) are growing in importance for the treatment of both solid and haematological malignancies. There is a demand for new payloads with novel mechanisms of action that may offer enhanced therapeutic efficacy, especially in patients who develop resistance. We report here a...

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Detalles Bibliográficos
Autores principales: Procopiou, George, Jackson, Paul J. M., di Mascio, Daniella, Auer, Jennifer L., Pepper, Chris, Rahman, Khondaker Miraz, Fox, Keith R., Thurston, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338023/
https://www.ncbi.nlm.nih.gov/pubmed/35906376
http://dx.doi.org/10.1038/s42003-022-03633-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338023/
https://www.ncbi.nlm.nih.gov/pubmed/35906376
http://dx.doi.org/10.1038/s42003-022-03633-0

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