NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation

Neural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrate that severe spinal contusion in adult rats causes transcriptional dysregulation, which pe...

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Detalles Bibliográficos
Autores principales: Martínez-Rojas, Beatriz, Giraldo, Esther, Grillo-Risco, Rubén, Hidalgo, Marta R., López-Mocholi, Eric, Alastrue-Agudo, Ana, García-García, Francisco, Moreno-Manzano, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338125/
https://www.ncbi.nlm.nih.gov/pubmed/35904607
http://dx.doi.org/10.1007/s00018-022-04494-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338125/
https://www.ncbi.nlm.nih.gov/pubmed/35904607
http://dx.doi.org/10.1007/s00018-022-04494-w

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