Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation

The loss of functional β-cell mass in type 2 diabetes (T2D) is associated with molecular events that include β-cell apoptosis, dysfunction and/or dedifferentiation. MicroRNA miR-184-3p has been shown to be involved in several β-cell functions, including insulin secretion, proliferation and survival....

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Detalles Bibliográficos
Autores principales: Grieco, Giuseppina E., Brusco, Noemi, Fignani, Daniela, Nigi, Laura, Formichi, Caterina, Licata, Giada, Marselli, Lorella, Marchetti, Piero, Salvini, Laura, Tinti, Laura, Po, Agnese, Ferretti, Elisabetta, Sebastiani, Guido, Dotta, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338237/
https://www.ncbi.nlm.nih.gov/pubmed/35906204
http://dx.doi.org/10.1038/s41420-022-01142-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338237/
https://www.ncbi.nlm.nih.gov/pubmed/35906204
http://dx.doi.org/10.1038/s41420-022-01142-x

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