Neprilysins regulate muscle contraction and heart function via cleavage of SERCA-inhibitory micropeptides

Muscle contraction depends on strictly controlled Ca(2+) transients within myocytes. A major player maintaining these transients is the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase, SERCA. Activity of SERCA is regulated by binding of micropeptides and impaired expression or function of these pep...

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Detalles Bibliográficos
Autores principales: Schiemann, Ronja, Buhr, Annika, Cordes, Eva, Walter, Stefan, Heinisch, Jürgen J., Ferrero, Paola, Milting, Hendrik, Paululat, Achim, Meyer, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338278/
https://www.ncbi.nlm.nih.gov/pubmed/35906206
http://dx.doi.org/10.1038/s41467-022-31974-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338278/
https://www.ncbi.nlm.nih.gov/pubmed/35906206
http://dx.doi.org/10.1038/s41467-022-31974-1

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