Argonaute 2 modulates EGFR–RAS signaling to promote mutant HRAS and NRAS-driven malignancies

Activating mutations in RAS GTPases drive nearly 30% of all human cancers. Our prior work described an essential role for Argonaute 2 (AGO2), of the RNA-induced silencing complex, in mutant KRAS-driven cancers. Here, we identified a novel endogenous interaction between AGO2 and RAS in both wild-type...

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Detalles Bibliográficos
Autores principales: Siebenaler, Ronald F, Chugh, Seema, Waninger, Jessica J, Dommeti, Vijaya L, Kenum, Carson, Mody, Malay, Gautam, Anudeeta, Patel, Nidhi, Chu, Alec, Bawa, Pushpinder, Hon, Jennifer, Smith, Richard D, Carlson, Heather, Cao, Xuhong, Tesmer, John J G, Shankar, Sunita, Chinnaiyan, Arul M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338400/
https://www.ncbi.nlm.nih.gov/pubmed/35923912
http://dx.doi.org/10.1093/pnasnexus/pgac084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338400/
https://www.ncbi.nlm.nih.gov/pubmed/35923912
http://dx.doi.org/10.1093/pnasnexus/pgac084

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