GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study

PURPOSE: GEN-1 (phIL-12-005/PPC), an IL12 plasmid formulated with polyethyleneglycol-polyethyleneimine cholesterol lipopolymer, has preclinical activity when combined with platinum-taxane intravenous chemotherapy and administered intraperitoneally in epithelial ovarian cancer (EOC) models. OVATION I...

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Detalles Bibliográficos
Autores principales: Thaker, Premal H., Bradley, William H., Leath, Charles A., Gunderson Jackson, Camille, Borys, Nicholas, Anwer, Khursheed, Musso, Lauren, Matsuzaki, Junko, Bshara, Wiam, Odunsi, Kunle, Alvarez, Ronald D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Clinical Trials: Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338778/
https://www.ncbi.nlm.nih.gov/pubmed/34326131
http://dx.doi.org/10.1158/1078-0432.CCR-21-0360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338778/
https://www.ncbi.nlm.nih.gov/pubmed/34326131
http://dx.doi.org/10.1158/1078-0432.CCR-21-0360

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