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A maternal high-fat diet induces fetal origins of NASH-HCC in mice

Maternal overnutrition affects offspring susceptibility to nonalcoholic steatohepatitis (NASH). Male offspring from high-fat diet (HFD)-fed dams developed a severe form of NASH, leading to highly vascular tumor formation. The cancer/testis antigen HORMA domain containing protein 1 (HORMAD1), one of...

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Detalles Bibliográficos
Autores principales: Takiyama, Takao, Sera, Toshihiro, Nakamura, Masanori, Hoshino, Masato, Uesugi, Kentaro, Horike, Shin-ichi, Meguro-Horike, Makiko, Bessho, Ryoichi, Takiyama, Yuri, Kitsunai, Hiroya, Takeda, Yasutaka, Sawamoto, Kazuki, Yagi, Naoto, Nishikawa, Yuji, Takiyama, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338981/
https://www.ncbi.nlm.nih.gov/pubmed/35907977
http://dx.doi.org/10.1038/s41598-022-17501-8