Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance

Acquired resistance to cetuximab in colorectal cancers is partially mediated by the acquisition of mutations located in the cetuximab epitope in the epidermal growth factor receptor (EGFR) ectodomain and hinders the clinical application of cetuximab. We develop a structure-guided and phage-assisted...

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Detalles Bibliográficos
Autores principales: Zhuang, Xinlei, Wang, Zhe, Fan, Jiansheng, Bai, Xuefei, Xu, Yingchun, Chou, James J., Hou, Tingjun, Chen, Shuqing, Pan, Liqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338999/
https://www.ncbi.nlm.nih.gov/pubmed/35907884
http://dx.doi.org/10.1038/s41467-022-32159-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338999/
https://www.ncbi.nlm.nih.gov/pubmed/35907884
http://dx.doi.org/10.1038/s41467-022-32159-6

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