Cargando…
Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance
Acquired resistance to cetuximab in colorectal cancers is partially mediated by the acquisition of mutations located in the cetuximab epitope in the epidermal growth factor receptor (EGFR) ectodomain and hinders the clinical application of cetuximab. We develop a structure-guided and phage-assisted...
Autores principales: | Zhuang, Xinlei, Wang, Zhe, Fan, Jiansheng, Bai, Xuefei, Xu, Yingchun, Chou, James J., Hou, Tingjun, Chen, Shuqing, Pan, Liqiang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338999/ https://www.ncbi.nlm.nih.gov/pubmed/35907884 http://dx.doi.org/10.1038/s41467-022-32159-6 |
Ejemplares similares
-
A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models
por: Fan, Jiansheng, et al.
Publicado: (2021) -
Identification of an Activating Mutation in the Extracellular Domain of HER2 Conferring Resistance to Pertuzumab
por: Zhang, Ying, et al.
Publicado: (2019) -
Facile Generation of Potent Bispecific Fab via Sortase A and Click Chemistry for Cancer Immunotherapy
por: Bai, Xuefei, et al.
Publicado: (2021) -
Clonal Evolution and Heterogeneity of Osimertinib Acquired Resistance Mechanisms in EGFR Mutant Lung Cancer
por: Roper, Nitin, et al.
Publicado: (2020) -
Historical Contingency Drives Compensatory Evolution and Rare Reversal of Phage Resistance
por: Debray, Reena, et al.
Publicado: (2022)