Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure

Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show that the hyperactive isoform of carbohydrate response-element binding protein (ChREBPβ) is a nuclear effector of hyperglycemic stress occurring in β-cells in response to prolonged glucose exposure, high-fat di...

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Detalles Bibliográficos
Autores principales: Katz, Liora S., Brill, Gabriel, Zhang, Pili, Kumar, Anil, Baumel-Alterzon, Sharon, Honig, Lee B., Gómez-Banoy, Nicolás, Karakose, Esra, Tanase, Marius, Doridot, Ludivine, Alvarsson, Alexandra, Davenport, Bennett, Wang, Peng, Lambertini, Luca, Stanley, Sarah A., Homann, Dirk, Stewart, Andrew F., Lo, James C., Herman, Mark A., Garcia-Ocaña, Adolfo, Scott, Donald K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339008/
https://www.ncbi.nlm.nih.gov/pubmed/35908073
http://dx.doi.org/10.1038/s41467-022-32162-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339008/
https://www.ncbi.nlm.nih.gov/pubmed/35908073
http://dx.doi.org/10.1038/s41467-022-32162-x

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