FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues. Multiple protein acyltransferase enzymes have been reported to post-translationally modify sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Mekhail, Katrina, Lee, Minhyoung, Sugiyama, Michael, Astori, Audrey, St-Germain, Jonathan, Latreille, Elyse, Khosraviani, Negar, Wei, Kuiru, Li, Zhijie, Rini, James, Lee, Warren L., Antonescu, Costin, Raught, Brian, Fairn, Gregory D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339154/
https://www.ncbi.nlm.nih.gov/pubmed/35921881
http://dx.doi.org/10.1016/j.jlr.2022.100256

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339154/
https://www.ncbi.nlm.nih.gov/pubmed/35921881
http://dx.doi.org/10.1016/j.jlr.2022.100256

Ejemplares similares