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FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues. Multiple protein acyltransferase enzymes have been reported to post-translationally modify sp...

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Detalles Bibliográficos
Autores principales:	Mekhail, Katrina, Lee, Minhyoung, Sugiyama, Michael, Astori, Audrey, St-Germain, Jonathan, Latreille, Elyse, Khosraviani, Negar, Wei, Kuiru, Li, Zhijie, Rini, James, Lee, Warren L., Antonescu, Costin, Raught, Brian, Fairn, Gregory D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339154/ https://www.ncbi.nlm.nih.gov/pubmed/35921881 http://dx.doi.org/10.1016/j.jlr.2022.100256

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