FMRP-dependent production of large dosage-sensitive proteins is highly conserved

Mutations in FMR1 are the most common heritable cause of autism spectrum disorder. FMR1 encodes an RNA-binding protein, FMRP, which binds to long, autism-relevant transcripts and is essential for normal neuronal and ovarian development. In contrast to the prevailing model that FMRP acts to block tra...

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Detalles Bibliográficos
Autores principales: Flanagan, Keegan, Baradaran-Heravi, Alireza, Yin, Qi, Dao Duc, Khanh, Spradling, Allan C, Greenblatt, Ethan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339308/
https://www.ncbi.nlm.nih.gov/pubmed/35731217
http://dx.doi.org/10.1093/genetics/iyac094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9339308/
https://www.ncbi.nlm.nih.gov/pubmed/35731217
http://dx.doi.org/10.1093/genetics/iyac094

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