Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals

Completion of the Lassa virus (LASV) life cycle critically depends on the activities of the virally encoded, RNA-dependent RNA polymerase in replication and transcription of the viral RNA genome in the cytoplasm of infected cells. The contribution of cellular proteins to these processes remains uncl...

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Detalles Bibliográficos
Autores principales: Fang, Jingru, Pietzsch, Colette, Witwit, Haydar, Tsaprailis, George, Crynen, Gogce, Cho, Kelvin Frank, Ting, Alice Y., Bukreyev, Alexander, Saphire, Erica Ollmann, de la Torre, Juan Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340056/
https://www.ncbi.nlm.nih.gov/pubmed/35858434
http://dx.doi.org/10.1073/pnas.2201208119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340056/
https://www.ncbi.nlm.nih.gov/pubmed/35858434
http://dx.doi.org/10.1073/pnas.2201208119

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