A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts

One important confounder in genome-wide association studies (GWASs) is population genetic structure, which may generate spurious associations if not properly accounted for. This may ultimately result in a biased polygenic risk score (PRS) prediction, especially when applied to another population. To...

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Detalles Bibliográficos
Autores principales: Pärna, Katri, Nolte, Ilja M., Snieder, Harold, Fischer, Krista, Marnetto, Davide, Pagani, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340200/
https://www.ncbi.nlm.nih.gov/pubmed/35923706
http://dx.doi.org/10.3389/fgene.2022.899523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340200/
https://www.ncbi.nlm.nih.gov/pubmed/35923706
http://dx.doi.org/10.3389/fgene.2022.899523

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