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A Principal Component Informed Approach to Address Polygenic Risk Score Transferability Across European Cohorts
One important confounder in genome-wide association studies (GWASs) is population genetic structure, which may generate spurious associations if not properly accounted for. This may ultimately result in a biased polygenic risk score (PRS) prediction, especially when applied to another population. To...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340200/ https://www.ncbi.nlm.nih.gov/pubmed/35923706 http://dx.doi.org/10.3389/fgene.2022.899523 |