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The role of efflux transporters and metabolizing enzymes in brain and peripheral organs to explain drug‐resistant epilepsy
Drug‐resistant epilepsy has been explained by different mechanisms. The most accepted one involves overexpression of multidrug transporters proteins at the blood brain barrier and brain metabolizing enzymes. This hypothesis is one of the main pharmacokinetic reasons that lead to the lack of response...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340310/ https://www.ncbi.nlm.nih.gov/pubmed/34560816 http://dx.doi.org/10.1002/epi4.12542 |