In Vitro–In Vivo Extrapolation by Physiologically Based Kinetic Modeling: Experience With Three Case Studies and Lessons Learned

Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning of the 21st century to support dose selection to be used in preclinical and clinical safety studies in the pharmaceutical sector. For chemical safety assessment, the use of PBK has also found interest, howeve...

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Detalles Bibliográficos
Autores principales: Algharably, Engi Abdelhady, Di Consiglio, Emma, Testai, Emanuela, Pistollato, Francesca, Mielke, Hans, Gundert-Remy, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340473/
https://www.ncbi.nlm.nih.gov/pubmed/35924078
http://dx.doi.org/10.3389/ftox.2022.885843

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340473/
https://www.ncbi.nlm.nih.gov/pubmed/35924078
http://dx.doi.org/10.3389/ftox.2022.885843

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