Uncoupling of Mitosis and Cytokinesis Upon a Prolonged Arrest in Metaphase Is Influenced by Protein Phosphatases and Mitotic Transcription in Fission Yeast

Depletion of the Anaphase-Promoting Complex/Cyclosome (APC/C) activator Cdc20 arrests cells in metaphase with high levels of the mitotic cyclin (Cyclin B) and the Separase inhibitor Securin. In mammalian cells this arrest has been exploited for the treatment of cancer with drugs that engage the spin...

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Detalles Bibliográficos
Autores principales: Chica, Nathalia, Portantier, Marina, Nyquist-Andersen, Mari, Espada-Burriel, Silvia, Lopez-Aviles, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340479/
https://www.ncbi.nlm.nih.gov/pubmed/35923846
http://dx.doi.org/10.3389/fcell.2022.876810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340479/
https://www.ncbi.nlm.nih.gov/pubmed/35923846
http://dx.doi.org/10.3389/fcell.2022.876810

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