Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Covalent attachment of methoxy poly(ethylene) glycol (mPEG) to therapeutic molecules is widely employed to improve their systemic circulation time and therapeutic efficacy. mPEG, however, can induce anti-PEG antibodies that negatively impact drug therapeutic effects. However, the underlying mechanis...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Minh-Tram T., Shih, Yu-Chien, Lin, Meng-Hsuan, Roffler, Steve R., Hsiao, Chiao-Yu, Cheng, Tian-Lu, Lin, Wen-Wei, Lin, En-Chi, Jong, Yuh-Jyh, Chang, Chin-Yuan, Su, Yu-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340711/
https://www.ncbi.nlm.nih.gov/pubmed/35936993
http://dx.doi.org/10.1038/s42004-022-00709-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340711/
https://www.ncbi.nlm.nih.gov/pubmed/35936993
http://dx.doi.org/10.1038/s42004-022-00709-0

Ejemplares similares