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Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group

Covalent attachment of methoxy poly(ethylene) glycol (mPEG) to therapeutic molecules is widely employed to improve their systemic circulation time and therapeutic efficacy. mPEG, however, can induce anti-PEG antibodies that negatively impact drug therapeutic effects. However, the underlying mechanis...

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Detalles Bibliográficos
Autores principales:	Nguyen, Minh-Tram T., Shih, Yu-Chien, Lin, Meng-Hsuan, Roffler, Steve R., Hsiao, Chiao-Yu, Cheng, Tian-Lu, Lin, Wen-Wei, Lin, En-Chi, Jong, Yuh-Jyh, Chang, Chin-Yuan, Su, Yu-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340711/ https://www.ncbi.nlm.nih.gov/pubmed/35936993 http://dx.doi.org/10.1038/s42004-022-00709-0

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