Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs

[Image: see text] A major limitation of pulmonary delivery is that drugs can exhibit suboptimal pharmacokinetic profiles resulting from rapid elimination from the pulmonary tissue. This can lead to systemic side effects and a short duration of action. A series of dibasic dipeptides attached to the p...

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Detalles Bibliográficos
Autores principales: Ayre, Jack, Redmond, Joanna M., Vitulli, Giovanni, Tomlinson, Laura, Weaver, Richard, Comeo, Eleonora, Bosquillon, Cynthia, Stocks, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340777/
https://www.ncbi.nlm.nih.gov/pubmed/35798565
http://dx.doi.org/10.1021/acs.jmedchem.2c00416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340777/
https://www.ncbi.nlm.nih.gov/pubmed/35798565
http://dx.doi.org/10.1021/acs.jmedchem.2c00416

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