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Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs
[Image: see text] A major limitation of pulmonary delivery is that drugs can exhibit suboptimal pharmacokinetic profiles resulting from rapid elimination from the pulmonary tissue. This can lead to systemic side effects and a short duration of action. A series of dibasic dipeptides attached to the p...
Autores principales: | Ayre, Jack, Redmond, Joanna M., Vitulli, Giovanni, Tomlinson, Laura, Weaver, Richard, Comeo, Eleonora, Bosquillon, Cynthia, Stocks, Michael J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340777/ https://www.ncbi.nlm.nih.gov/pubmed/35798565 http://dx.doi.org/10.1021/acs.jmedchem.2c00416 |
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