Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5

[Image: see text] Sirtiun 5 (SIRT5) is a NAD(+)-dependent protein lysine deacylase primarily located in mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly catalyzes lysine deglutarylation, desuccinylation, and demalonylation while possessing weak deacetylase activ...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiorentino, Francesco, Castiello, Carola, Mai, Antonello, Rotili, Dante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340778/
https://www.ncbi.nlm.nih.gov/pubmed/35802779
http://dx.doi.org/10.1021/acs.jmedchem.2c00687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340778/
https://www.ncbi.nlm.nih.gov/pubmed/35802779
http://dx.doi.org/10.1021/acs.jmedchem.2c00687

Ejemplares similares