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Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5

[Image: see text] Sirtiun 5 (SIRT5) is a NAD(+)-dependent protein lysine deacylase primarily located in mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly catalyzes lysine deglutarylation, desuccinylation, and demalonylation while possessing weak deacetylase activ...

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Detalles Bibliográficos
Autores principales:	Fiorentino, Francesco, Castiello, Carola, Mai, Antonello, Rotili, Dante
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9340778/ https://www.ncbi.nlm.nih.gov/pubmed/35802779 http://dx.doi.org/10.1021/acs.jmedchem.2c00687

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