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A cyanide-catalyzed imino-Stetter reaction enables the concise total syntheses of rucaparib
Two routes toward the synthesis of rucaparib, an FDA-approved drug used for the treatment of ovarian and prostate cancers, have been developed from commercially available starting materials utilizing the cyanide-catalyzed imino-Stetter reaction as the key step for the construction of the indole moti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341288/ https://www.ncbi.nlm.nih.gov/pubmed/35975042 http://dx.doi.org/10.1039/d2ra03619c |