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A cyanide-catalyzed imino-Stetter reaction enables the concise total syntheses of rucaparib

Two routes toward the synthesis of rucaparib, an FDA-approved drug used for the treatment of ovarian and prostate cancers, have been developed from commercially available starting materials utilizing the cyanide-catalyzed imino-Stetter reaction as the key step for the construction of the indole moti...

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Detalles Bibliográficos
Autores principales: Park, Jinjae, Cheon, Cheol-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341288/
https://www.ncbi.nlm.nih.gov/pubmed/35975042
http://dx.doi.org/10.1039/d2ra03619c