High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation

Genomic rearrangements are known to result in proto-oncogene deregulation in many cancers, but the link to 3D genome structure remains poorly understood. Here, we used the highly predictive heteromorphic polymer (HiP-HoP) model to predict chromatin conformations at the proto-oncogene CCND1 in health...

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Detalles Bibliográficos
Autores principales: Rico, Daniel, Kent, Daniel, Karataraki, Nefeli, Mikulasova, Aneta, Berlinguer-Palmini, Rolando, Walker, Brian A., Javierre, Biola M., Russell, Lisa J., Brackley, Chris A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341513/
https://www.ncbi.nlm.nih.gov/pubmed/35863900
http://dx.doi.org/10.1101/gr.276028.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341513/
https://www.ncbi.nlm.nih.gov/pubmed/35863900
http://dx.doi.org/10.1101/gr.276028.121

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