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Improved process intermediate stability through the identification and elimination of reactive glycation residues – a monoclonal antibody case study
The manufacturing of therapeutic biologics can result in a heterogeneous population of charge variants, encompassing many quality attributes which could impact activity and pharmacokinetics. Monitoring the relative abundance of these charge variants to demonstrate process consistency is an expectati...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342189/ https://www.ncbi.nlm.nih.gov/pubmed/35757891 http://dx.doi.org/10.1080/21655979.2022.2086350 |