Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma

INTRODUCTION: Adrenocortical carcinoma (ACC) is a rare aggressive cancer with low overall survival. Adjuvant mitotane improves survival but is limited by poor response rates and resistance. Mitotane’s efficacy is attributed to the accumulation of toxic free cholesterol, predominantly through cholest...

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Detalles Bibliográficos
Autores principales: Warde, Kate M, Lim, Yi Jan, Ribes Martinez, Eduardo, Beuschlein, Felix, O’Shea, Paula, Hantel, Constanze, Dennedy, Michael Conall
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342684/
https://www.ncbi.nlm.nih.gov/pubmed/35797592
http://dx.doi.org/10.1210/endocr/bqac102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342684/
https://www.ncbi.nlm.nih.gov/pubmed/35797592
http://dx.doi.org/10.1210/endocr/bqac102

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