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To what extent naringenin binding and membrane depolarization shape mitoBK channel gating—A machine learning approach

The large conductance voltage- and Ca(2+)-activated K(+) channels from the inner mitochondrial membrane (mitoBK) are modulated by a number of factors. Among them flavanones, including naringenin (Nar), arise as a promising group of mitoBK channel regulators from a pharmacological point of view. It i...

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Detalles Bibliográficos
Autores principales: Richter-Laskowska, Monika, Trybek, Paulina, Bednarczyk, Piotr, Wawrzkiewicz-Jałowiecka, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342765/
https://www.ncbi.nlm.nih.gov/pubmed/35857767
http://dx.doi.org/10.1371/journal.pcbi.1010315