CORM-3 induces DNA damage through Ru(II) binding to DNA

When the ‘CO-releasing molecule-3’, CORM-3 (Ru(CO)(3)Cl(glycinate)), is dissolved in water it forms a range of ruthenium complexes. These are taken up by cells and bind to intracellular ligands, notably thiols such as cysteine and glutathione, where the Ru(II) reaches high intracellular concentratio...

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Detalles Bibliográficos
Autores principales: Lyon, Rhiannon F., Southam, Hannah M., Trevitt, Clare R., Liao, Chunyan, El-Khamisy, Sherif F., Poole, Robert K., Williamson, Mike P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342897/
https://www.ncbi.nlm.nih.gov/pubmed/35726678
http://dx.doi.org/10.1042/BCJ20220254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342897/
https://www.ncbi.nlm.nih.gov/pubmed/35726678
http://dx.doi.org/10.1042/BCJ20220254

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