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µ-Theraphotoxin Pn3a inhibition of Ca(V)3.3 channels reveals a novel isoform-selective drug binding site
Low voltage-activated calcium currents are mediated by T-type calcium channels Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. Ca(V)3 isoforms’ biophysical properties, overlapping expression, and lack of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342953/ https://www.ncbi.nlm.nih.gov/pubmed/35858123 http://dx.doi.org/10.7554/eLife.74040 |