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µ-Theraphotoxin Pn3a inhibition of Ca(V)3.3 channels reveals a novel isoform-selective drug binding site

Low voltage-activated calcium currents are mediated by T-type calcium channels Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3, which modulate a variety of physiological processes including sleep, cardiac pace-making, pain, and epilepsy. Ca(V)3 isoforms’ biophysical properties, overlapping expression, and lack of...

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Detalles Bibliográficos
Autores principales:	McArthur, Jeffrey R, Wen, Jierong, Hung, Andrew, Finol-Urdaneta, Rocio K, Adams, David J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342953/ https://www.ncbi.nlm.nih.gov/pubmed/35858123 http://dx.doi.org/10.7554/eLife.74040

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